Endocrine Abstracts

Agranulocytosis is a well recognised but rare side effect of carbimazole therapy which usually occurs within the first 3 months of treatment .We report the case of a 55 year old woman with Graves disease, who developed delayed carbimazole induced agranulocytosis, precipitating a thyroid crisis.Our patient presented with clinical and biochemical evidence of hyperthyroidism in 1998. She was treated with carbimazole and thyroxine in a standard block and replace regimen, this was ...

IntroductionPrimary hyperparathyroidism (PHP) due to adenoma or hyperplasia is common and is being increasingly diagnosed. Overall 80% are due to single adenoma, 15% to multiglandular hyperplasia, 3% to multiple adenomata (usually 2) and 2% to carcinoma. In 20-30% the glands will be ectopically placed, usually within the neck, though can be anywhere from the skull base to the diaphragm.Surgery is the treatment and a longterm debate...

The teratogenic effects of diabetes and the diabetogenic effects of pregnancy make tight glycaemic control during gestation essential. Regular review of the patients is neccessary though the short intervals between appointments make the relatively slow-to-change HbA1c unsuitable for making clinical decisions. Instead, the clinician must rely on home blood glucose (HBG)monitoring results from the patient. These depend on having an accurate meter and good technique aswell as hon...